The Diabetes Genome Anatomy Project (DGAP) represents a unique, multidimensional initiative whose goal is to unravel the interface between insulin action, insulin resistance and the genetics of type 2 diabetes. The project was developed in conjunction with NIDDK in response to the report of the Diabetes Research Working Group and represents the efforts of investigators from five institutions. There are six projects and four cores that form a highly interactive matrix and also serve as a scaffold on which to build future projects or interactions with related projects and grants.
The overall goal of the project is to identify the sets of the genes and gene products involved in insulin action and the predisposition to type 2 diabetes, as well as the secondary changes in gene expression that occur in response to the metabolic abnormalities present in diabetes. There are five major and one pilot project involving human and rodent tissues that are designed to:
The resultant information will be used to create a highly annotated and interactive public database, standardized protocols for gene expression and proteomic analysis, and ultimately diabetes-specific and insulin action-specific DNA chips for investigators in the field. In this manner, the DGAP project will define:
This project and the resultant database will aid investigators in the quest to unravel the complexity of insulin action and its alterations in diabetes, and ultimately help develop more effective and specific modes for classification, metabolic staging and therapy of the disease.
Copyright © 2002 by Diabetes Genome Anatomy Project. All rights reserved. All documents on this Web site are the property of Diabetes Genome Anatomy Project and are protected by copyright. Any reproduction of any document on this Web site which omits Joslin's name or copyright notice is prohibited. Documents on this Web site may be reproduced for personal use only. They may not be distributed or sold. They may not be published in any other format (e.g., book, article, Web site) without the prior, written permission of Diabetes Genome Anatomy Project.
Please contact the webmaster with questions, comments, or suggestions.